125312-94-9Relevant articles and documents
Mild Darzens Annulations for the Assembly of Trifluoromethylthiolated (SCF3) Aziridine and Cyclopropane Structures
Delost, Michael D.,Njardarson, Jon T.
supporting information, p. 6121 - 6125 (2021/08/16)
We report mild new annulation approaches to trisubstituted trifluoromethylthiolated (SCF3) aziridines and cyclopropanes via Darzens inspired protocols. The products of these anionic annulations, rarely studied previously, possess attractive features rendering them valuable building blocks for synthesis platforms. In this study, trisubstituted acetophenone nucleophiles bearing SCF3 and bromine substituents in their α position were shown to undergo [2 + 1] annulations with vinyl ketones and tosyl-protected imines under mild reaction conditions.
Synthesis of β-ketophosphonates via AgNO3-catalyzed hydration of alkynylphosphonates: A rate-enhancement effect of methanol
Xiang, Jiannan,Yi, Niannian,Wang, Ruijia,Lu, Linghui,Zou, Huaxu,Pan, Yuan,He, Weimin
, p. 694 - 699 (2015/02/02)
β-Ketophosphonates were prepared via AgNO3-catalyzed hydration of alkynylphosphonates with a dramatic rate-enhancement effect of methanol. This benign aqueous-methanol method catalyzed by a low-cost catalyst has simple, atom-economical procedure, and was used effectively with a wide range of substrates.
Noncovalent organocatalytic synthesis of enantioenriched terminal aziridines with a quaternary stereogenic center
De Fusco, Claudia,Fuoco, Tiziana,Croce, Gianluca,Lattanzi, Alessandra
supporting information; experimental part, p. 4078 - 4081 (2012/09/21)
A high-yielding and enantioselective access to novel N-Boc terminal aziridines, bearing a quaternary stereogenic center, has been developed via an aza-Michael initiated ring-closure (aza-MIRC) reaction of α-acyl acrylates with an N-tosyloxy tert-butyl carbamate catalyzed by a chiral amino thiourea. The feasibility of the aziridine regioselective ring-opening to valuable α,α-disubstituted α-amino acid esters has been demonstrated.
Discovery of powerful uranyl ligands from efficient synthesis and screening
Sawicki, Marcin,Siaugue, Jean-Michel,Jacopin, Christophe,Moulin, Christophe,Bailly, Theodorine,Burgada, Ramon,Meunier, Stephane,Baret, Paul,Pierre, Jean-Louis,Taran, Frederic
, p. 3689 - 3697 (2007/10/03)
New tripodal gem-(bis-phosphonates) uranophiles were discovered by a screening method that allowed for the selection of ligands with strong uranyl-binding properties in a convenient microtiter-plate format. The method is based on competitive uranium bindi
