125313-88-4

Basic information

• Product Name: 1H-Pyrrole-2,5-dione, 3-(1-methyl-1H-indol-3-yl)-4-[1-(phenylmethyl)-1H-indol-3-yl]-
• CAS NO: 125313-88-4
• Molecular Formula: C28H21N3O2
• Molecular Weight: 431.494
• Mol File: 125313-88-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-2,5-dione, 3-(1-methyl-1H-indol-3-yl)-4-[1-(phenylmethyl)-1H-indol-3-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2,5-dione, 3-(1-methyl-1H-indol-3-yl)-4-[1-(phenylmethyl)-1H-indol-3-yl]-(125313-88-4)
• EPA Substance Registry System: 1H-Pyrrole-2,5-dione, 3-(1-methyl-1H-indol-3-yl)-4-[1-(phenylmethyl)-1H-indol-3-yl]-(125313-88-4)

Safety Data

• Hazardous Substances Data: 125313-88-4(Hazardous Substances Data)

Upstream product

• 128760-90-7 3-(1-Benzyl-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-furan-2,5-dione 
• 4307-97-5 N-benzylindole-3-acetic acid 
• 16382-38-0 1-methylindole-3-glyoxylyl chloride 

Relevant articles and documents

Inhibitors of Protein Kinase C. 1. 2,3-Bisarylmaleimides

The design and synthesis of a series of novel inhibitors of protein kinase C (PKC) is described.These 2,3-bisarylmaleimides were derived from the structural lead provided by the indolocarbazoles, staurosporine and K252a.Optimum activity required the imide NH, both carbonyl groups, and the olefinic bond of the maleimide ring. 2,3-Bisindolylmaleimides were the most active, and the potency of these was improved by a chloro substituent at the 5-position of one indole ring (compound 28, IC50 0.11 μM).In a series of (phenylindolyl)maleimides, nitro compound 74 was most active (IC50 0.67 μM).Naphthalene 19 and benzothiophene 21 showed greater than 100-fold selectivity for inhibition of PKC over the closely related cAMP-dependent protein kinase (PKA).