1253183-75-3

Upstream product

• 1253183-68-4 methyl [2-O-benzoyl-3-O-benzyl-6-O-chloroacetyl-4-O-(1-naphthylmethyl)-β-D-glucopyranosyl]-(1->4)-(2-acetamido-3,6-di-O-benzyl-2-deoxy-α-D-glucopyranoside) 

Downstream Products

• 1253183-79-7 methyl [tert-butyl (2-O-benzoyl-3,4-di-O-benzyl-β-D-glucopyranosyl)uronate]-(1->4)-(2-azido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranosyl)-(1->4)-(2-O-benzoyl-3-O-benzyl-6-O-chloroacetyl-β-D-glucopyranosyl)-(1->4)-(2-acetamido-3,6-di-O-benzyl-2-deoxy-α-D-glucopyranoside) 
• 1253183-77-5 methyl [tert-butyl (2-O-benzoyl-3,4-di-O-benzyl-β-D-glucopyranosyl)uronate]-(1->4)-(2-azido-3,6-di-O-benzyl-2-deoxy-α-D-glucopyranosyl)-(1->4)-(2-O-benzoyl-3-O-benzyl-6-O-chloroacetyl-β-D-glucopyranosyl)-(1->4)-(2-acetamido-3,6-di-O-benzyl-2-deoxy-α-D-glucopyranoside) 

Relevant academic research and scientific papers

Synthesis of glycosaminoglycan oligosaccharides. Part 5: Synthesis of a putative heparan sulfate tetrasaccharide antigen involved in prion diseases

The synthesis of the putative prion-associated heparan sulfate tetrasaccharide containing two d-glucuronic acid units is reported. Key to the synthesis were the differentiation of the N-acetylated and N-unsubstituted glucosamine units, the high-yielding glucosylation at O-4 of an N-acetyl-d-glucosamine derivative and the α-selective glycosylation of the 4′-OH group of a β-d-GlcpA-(1→4)-d-GlcpNAc disaccharide building block with a disaccharide thioglycoside donor.