1253299-13-6

Basic information

• Product Name: 3,5-bis(3-methoxyphenyl)-1,2,4-thiadiazole
• Synonyms: 3,5-bis(3-methoxyphenyl)-1,2,4-thiadiazole
• CAS NO: 1253299-13-6
• Molecular Weight: 298.365
• Mol File: 1253299-13-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3,5-bis(3-methoxyphenyl)-1,2,4-thiadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-bis(3-methoxyphenyl)-1,2,4-thiadiazole(1253299-13-6)
• EPA Substance Registry System: 3,5-bis(3-methoxyphenyl)-1,2,4-thiadiazole(1253299-13-6)

Safety Data

• Hazardous Substances Data: 1253299-13-6(Hazardous Substances Data)

Upstream product

• 64559-06-4 3-methoxythiobenzamide 
• 1527-89-5 3-methoxybenzonitrile 

Downstream Products

• 1078733-79-5 3,3'-(1,2,4-thiadiazole-3,5-diyl)diphenol 

Relevant articles and documents

Aerobic Visible-Light Induced Intermolecular S?N Bond Construction: Synthesis of 1,2,4-Thiadiazoles from Thioamides under Photosensitizer-Free Conditions

Aerobic visible-light induced intermolecular S?N bond construction has been achieved without the addition of photosensitizer, metal, or base. With this strategy, 1,2,4-thiadiazoles can be obtained from thioamides. Preliminary mechanistic investigation suggested that the excited state of thioamides undergoes a single-electron-transfer (SET) process to afford thioamidyl radicals, which can be further transformed into a 1,2,4-thiadiazole through desulfurization and oxidative cyclization. The reaction has good functional group tolerance and represents a green method for the construction of S?N bonds.

Electrochemical Synthesis of 3,5-Disubstituted-1,2,4-thiadiazoles through NH4I-Mediated Dimerization of Thioamides

A electrochemical method for the synthesis of 3,5-disubstituted-1,2,4-thiadiazoles through NH4I-mediated dimerization of thioamides is reported. Using the inexpensive NH4I as electrolyte and catalyst, this electrosynthesis approach requires no oxidizing agents and enables the convenient production of diverse 1,2,4-thiadiazoles products. The approach is an example of S?N bond construction through the electrochemical method. (Figure presented.).