1253379-80-4

Basic information

• Product Name: 1-(4-bromo-2-methylphenyl)-4-[(2-chloro-4-fluorophenyl)methyl]-2,3-piperazinedione
• Synonyms: 1-(4-bromo-2-methylphenyl)-4-[(2-chloro-4-fluorophenyl)methyl]-2,3-piperazinedione
• CAS NO: 1253379-80-4
• Molecular Weight: 425.685
• Mol File: 1253379-80-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-bromo-2-methylphenyl)-4-[(2-chloro-4-fluorophenyl)methyl]-2,3-piperazinedione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-bromo-2-methylphenyl)-4-[(2-chloro-4-fluorophenyl)methyl]-2,3-piperazinedione(1253379-80-4)
• EPA Substance Registry System: 1-(4-bromo-2-methylphenyl)-4-[(2-chloro-4-fluorophenyl)methyl]-2,3-piperazinedione(1253379-80-4)

Safety Data

• Hazardous Substances Data: 1253379-80-4(Hazardous Substances Data)

Upstream product

• 1253380-72-1 methyl [[(2-chloro-4-fluorophenyl)methyl](2-oxoethyl)amino](oxo)acetate 
• 583-75-5 4-Bromo-2-methylaniline 

Relevant articles and documents

DIKETOPIPERAZINE DERIVATIVES AS P2X7 MODULATORS

The invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof: (I) wherein: A represents an aryl, heteroaryl or heterocyclyl group; and any ring or ring system of said aryl or heteroaryl is optionally substituted with 1 to 3 substituents, which may be the same or different, selected from the group consisting of halogen, C1-6 alkyl, -CF3, - OCF3, cyano, C1-6 alkoxy, -NR10R11, -X-aryl, -X-heteroaryl and -X-heterocyclyl; R1, R2, R3, R4 and R5 independently represent hydrogen, fluorine, chlorine, -CF3, cyano or C1-6 alkyl, such that at least one of R1, R2, R3, R4 and R5 is other than hydrogen; R6, R7, R8, R9, R10 and R11 independently represent hydrogen or C1-6 alkyl; X represents a linker selected from a bond, -(CH2)n- and -O-(CH2)n-; and n represents an integer from 1 to 3. The compounds or salts modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2X7 receptor ("P2X7 receptor antagonists").