1253385-33-9Relevant academic research and scientific papers
Expedient enantioselective synthesis of the Δ4-oxocene cores of (+)-laurencin and (+)-prelaureatin
Li, Jim,Suh, Judy M.,Chin, Elbert
supporting information; experimental part, p. 4712 - 4715 (2010/12/25)
An expedient enantioselective synthesis of the Δ4-oxocene cores present in (+)-laurencin and (+)-prelaureatin was accomplished in eight steps via a novel one-pot regio- and stereoselective ring cyclization- fragmentation-expansion cascade from the tetrahydrofuran precursors which were prepared by stereocontrolled cyclization from vinylsilanes. This process is highlighted by an intramolecular oxo-carbenoid insertion and a β-silyl fragmentation sequence.
