1253388-60-1

Basic information

• Product Name: C₂₈H₂₁NO
• Synonyms: C₂₈H₂₁NO
• CAS NO: 1253388-60-1
• Molecular Weight: 387.481
• Mol File: 1253388-60-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₂₈H₂₁NO(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₂₁NO(1253388-60-1)
• EPA Substance Registry System: C₂₈H₂₁NO(1253388-60-1)

Safety Data

• Hazardous Substances Data: 1253388-60-1(Hazardous Substances Data)

Upstream product

• 23099-05-0 3-methyl-N-phenylbenzamide 
• 501-65-5 diphenyl acetylene 

Relevant articles and documents

Nickel-catalyzed C-O/N-H, C-S/N-H, and C-CN/N-H annulation of aromatic amides with alkynes: C-O, C-S, and C-CN activation

The Ni-catalyzed reaction ofortho-phenoxy-substituted aromatic amides with alkynes in the presence of LiOtBu as a base results in C-O/N-H annulation with the formation of 1(2H)-isoquinolinones. The use of a base is essential for the reaction to proceed. The reaction proceeds, even in the absence of a ligand, and under mild reaction conditions (40 °C). An electron-donating group on the aromatic ring facilitates the reaction. The reaction was also applicable to carbamate (C-O bond activation), methylthio (C-S bond activation), and cyano (C-CN bond activation) groups as leaving groups.

Rh-catalyzed oxidative coupling between primary and secondary benzamides and alkynes: Synthesis of polycyclic amides

A methodology for the high yield and facile synthesis of isoquinolones from benzamides and alkynes via the oxidative ortho C-H activation of benzamides has been developed. Ag2CO3 proved to be an optimal oxidant when MeCN was used as