1253424-10-0

Basic information

• Product Name: 4-methoxy-N-(2-bromo-2,2-difluoroethylidene)aniline
• Synonyms: 4-methoxy-N-(2-bromo-2,2-difluoroethylidene)aniline
• CAS NO: 1253424-10-0
• Molecular Weight: 264.069
• Mol File: 1253424-10-0.mol

Chemical Properties

• CAS DataBase Reference: 4-methoxy-N-(2-bromo-2,2-difluoroethylidene)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxy-N-(2-bromo-2,2-difluoroethylidene)aniline(1253424-10-0)
• EPA Substance Registry System: 4-methoxy-N-(2-bromo-2,2-difluoroethylidene)aniline(1253424-10-0)

Safety Data

• Hazardous Substances Data: 1253424-10-0(Hazardous Substances Data)

Upstream product

• 104-94-9 4-methoxy-aniline 
• 201231-66-5 2-Bromo-1-ethoxy-2,2-difluoro-ethanol 

Downstream Products

• 1391088-97-3 benzyl (2S,4S)-2-(bromodifluoromethyl)-6-methoxy-1,2,3,4-tetrahydroquinolin-4-ylcarbamate 
• 1428259-69-1 (2R,4R,5R)-methyl 5-(bromodifluoromethyl)-1-(4-methoxyphenyl)-2-butylimidazolidine-4-carboxylate 
• 1428259-70-4 (2R,4R,5R)-methyl 5-(bromodifluoromethyl)-2-pentyl-1-(4-methoxyphenyl)imidazolidine-4-carboxylate 
• 1428259-65-7 (2R,4R,5R)-methyl 5-(bromodifluoromethyl)-1-(4-methoxyphenyl)-2-(naphthalen-2-yl)imidazolidine-4-carboxylate 
• 1454268-45-1 (R)-4-methoxy-N-(2,2,2-trifluoro-1-(phenylthio)ethyl)aniline 
• 1454268-44-0 (R)-N-(1-(benzylthio)-2-bromo-2,2-difluoroethyl)-4-methoxyaniline 
• 912820-62-3 2-(bromodifluoromethyl)-6-methoxyl-4-phenylquinoline 

Relevant articles and documents

The asymmetric synthesis of CF3- or -CF2-substituted tetrahydroquinolines by employing a chiral phosphoric acid as catalyst

CF3- or -CF2-containing tetrahydroquinolines have been asymmetrically synthesized from the reaction of fluorinated N-arylimines with benzyl N-vinylcarbamate in the presence of a chiral phosphoric acid.

Copper(I)-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Ylides with Fluorinated Imines: The Expanded Scope and Mechanism Insights

The mechanism of the Cu(I)/(S,Rp)-PPFOMe-catalyzed 1,3-dipolar cycloaddition of azomethine ylides with fluorinated aldimines has been studied using labeling experiments, control experiments, and linear effect experiments, which clearly ruled out the 1,3-DC/epimerization pathways and explained the unusal exo′-selective stereochemistry. This protocol allows for the preparation of a series of highly functionalized fluorinated imidazolidines in good yields with excellent stereoselectivities. Moreover, the current methods have been successfully extended to synthesize more challenging imidazolidines bearing a CF3-containing quaternary stereogenic center via the endo-selective 1,3-DC of azomethine ylides with trifluorinated ketimine under identical reaction conditions.