1253519-08-2Relevant academic research and scientific papers
Palladium(II)-catalyzed enantioselective synthesis of α- (trifluoromethyl)arylmethylamines
Johnson, Thomas,Lautens, Mark
supporting information, p. 4043 - 4045 (2013/09/12)
Trifluoromethylacetaldimines, generated in situ from the corresponding N,O-acetals, undergo 1,2-addition of arylboroxines under palladium(II) catalysis to generate a variety of α-(trifluoromethyl)arylmethylamines with good to high enantioselectivity (up to 97% ee). The pyridine-oxazolidine (PyOX) class of ligands was found to be particularly suitable for this transformation, which proceeds without exclusion of ambient air and moisture.
