1253573-41-9Relevant academic research and scientific papers
An efficient approach to the synthesis of enantiomerically pure trans-1-amino-2-(hydroxymethyl)cyclopropanephosphonic acids
Wasek, Katarzyna,Kedzia, Jacek,Krawczyk, Henryk
, p. 2081 - 2086 (2010)
The synthesis of (1R,2S)- and (1S,2R)-1-amino-2-(hydroxymethyl) cyclopropanephosphonic acids was accomplished using different strategies. The (1R,2S)-stereoisomer could be efficiently obtained by the cyclopropanation of ethyl diethoxyphosphorylacetate with the cyclic sulfate derived from (S)-3-benzyloxy-1,2-propandiol as a key step. The (1S,2R)-stereoisomer was synthesized from a readily available (1S,5R)-3-oxabicyclo[3.1.0]hexan-2-on-1- phosphonate.
