1253579-70-2Relevant academic research and scientific papers
Diaryl-substituted ortho-carboranes as a new class of hypoxia inducible factor-1α inhibitors
Nakamura, Hiroyuki,Tasaki, Lisa,Kanoh, Daisuke,Sato, Shinichi,Ban, Hyun Seung
, p. 4941 - 4944 (2014/04/03)
Diaryl-substituted ortho-carboranes 1 were synthesized from the corresponding alkynes by decaborane coupling under microwave-irradiated conditions with a combination of N,N-dimethylaniline and chlorobenzene. Among the compounds synthesized, 1a and 1d exhibited significant inhibition of hypoxia-induced HIF-1 transcriptional activity. Both compounds similarly suppressed hypoxia-induced HIF-1α accumulation in a concentration- dependent manner without affecting HIF-1α mRNA expression.
A general palladium-catalyzed sonogashira coupling of aryl and heteroaryl tosylates
R'kyek, Omar,Halland, Nis,Lindenschmidt, Andreas,Alonso, Jorge,Lindemann, Peter,Urmann, Matthias,Nazare, Marc
supporting information; experimental part, p. 9986 - 9989 (2010/11/16)
Coupled up: A new general palladium-catalyzed procedure for the cross-coupling of aryl and heteroaryl tosylates is described. This highly versatile and efficient process can be used for the synthesis of a wide variety of functionalized alkynes (see scheme).
