1253595-81-1

Basic information

• Product Name: ethyl (5R,αR)-5-(2-tert-butoxycarbonylamino-2-methoxycarbonylethyl)-4,5-dihydro-1-phenyl-1H-pyrazole-3-carboxylate
• CAS NO: 1253595-81-1
• Molecular Weight: 419.478
• Mol File: 1253595-81-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl (5R,αR)-5-(2-tert-butoxycarbonylamino-2-methoxycarbonylethyl)-4,5-dihydro-1-phenyl-1H-pyrazole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (5R,αR)-5-(2-tert-butoxycarbonylamino-2-methoxycarbonylethyl)-4,5-dihydro-1-phenyl-1H-pyrazole-3-carboxylate(1253595-81-1)
• EPA Substance Registry System: ethyl (5R,αR)-5-(2-tert-butoxycarbonylamino-2-methoxycarbonylethyl)-4,5-dihydro-1-phenyl-1H-pyrazole-3-carboxylate(1253595-81-1)

Safety Data

• Hazardous Substances Data: 1253595-81-1(Hazardous Substances Data)

Upstream product

• 28663-68-5 ethyl (phenylhydrazono)chloroacetate 
• 150652-96-3 (R)-2-(tert-butoxycarbonyl)amino-4-pentenoic acid methyl ester 

Downstream Products

• 1350901-08-4 C₁₈H₂₃N₃O₆ 
• 1253595-90-2 (5R,αR)-5-(2-amino-2-carboxyethyl)-4,5-dihydro-1-phenyl-1H-pyrazole-3-carboxylic acid 

Relevant articles and documents

Novel 3-carboxy-and 3-phosphonopyrazoline amino acids as potent and selective NMDA receptor antagonists: Design, synthesis, and pharmacological characterization

The design and synthesis of new N1-substituted 3-carboxyand 3-phosphonopyrazoline and pyrazole amino acids that target the glutamate binding site of NMDA receptors are described. An analysis of the stereochemical requirements for high-affinity interaction with these receptors was performed. We identified two highly potent and selective competitive NMDA receptor antagonists, (5S,αR)-1 and (5S,αR)-4, which exhibit good in vitro neuroprotective activity and in vivo anticonvulsant activity by i.p. administration, suggesting that these molecules may have potential use as therapeutic agents.