1253641-63-2Relevant academic research and scientific papers
Discovery of 1-(2,4-dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl) phenyl)ethynyl)thiophen-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a potential peripheral cannabinoid-1 receptor inverse agonist
Hung, Ming-Shiu,Chang, Chun-Ping,Li, Ting-Chieh,Yeh, Teng-Kuang,Song, Jen-Shin,Lin, Yinchiu,Wu, Chien-Huang,Kuo, Po-Chu,Amancha, Prashanth K.,Wong, Ying-Chieh,Hsiao, Wen-Chi,Chao, Yu-Sheng,Shia, Kak-Shan
, p. 1439 - 1443 (2010)
Fast food nation! The title compound (pictured) was identified as a potential peripheral CB1-acting antagonist based on its negative central effects in CB1R agonist-induced hypothermia and analgesia models, and low brain exposure as indicated by the blood-to-plasma ratio. This compound represents a potential lead in the treatment of metabolic disorders. (Chemical Equation Presented)
