1253660-23-9Relevant articles and documents
INDOLE-2-CARBOXAMIDE DERIVATIVE
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Page/Page column 19-20, (2010/11/17)
To provide an indole compound having a human QRFP receptor antagonistic activity and useful as a preventive or a remedy for various disorders. A compound of a formula (I) or a pharmaceutically-acceptable salt thereof is provided: [wherein, R1 represents a hydrogen atom, a halogen, a C1-6 alkyl, etc,; R2 represents a C1-6 alkyl, or a halo-C1-6 alkyl; R3 represents a hydrogen atom, a C1-6 alkyl, etc.; R4 represents a hydrogen atom, a C1-6 alkyl, a halo-C1-6 alkyl, etc.; or R3 and R4, taken together with the nitrogen atom to which they bond, form a 3- to 6-membered aliphatic nitrogen-containing hetero ring; or R3 and Y3, taken together, form -CH2-CH2-; Y1 and Y2 are both hydrogen atoms; or Y1 and Y2, taken together, form -CH2-CH2-; and Y3 represents a hydrogen atom; or Y3 and R3, taken together, form -CH2-CH2-].