1253855-29-6

Basic information

• Product Name: 4-(1-phenylethyl)-3-(thiophen-2-ylmethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one
• CAS NO: 1253855-29-6
• Molecular Weight: 285.37
• Mol File: 1253855-29-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(1-phenylethyl)-3-(thiophen-2-ylmethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1-phenylethyl)-3-(thiophen-2-ylmethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one(1253855-29-6)
• EPA Substance Registry System: 4-(1-phenylethyl)-3-(thiophen-2-ylmethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one(1253855-29-6)

Safety Data

• Hazardous Substances Data: 1253855-29-6(Hazardous Substances Data)

Upstream product

• 39978-18-2 2?(thiophen?2?yl)acetohydrazide 
• 14649-03-7 1-phenylethylisocyanate 

Relevant articles and documents

Synthesis and antibacterial evaluation of some semicarbazides and 1,2,4-triazol-5-ones containing thiophene moieties

In this study, some 3-(thiophen-2-ylmethyl)-4-substituted-4,5-dihydro-1H-1, 2,4-triazol-5-one derivatives were synthesized by the cyclization reaction of 1-(thiophen-2-ylacetyl)-4-substituted semicarbazide derivatives in alkaline medium or in the immediate reaction of thiophen-2-yl-acetic acid hydrazide with isocyanates. The structures of all new compounds were confirmed by analytical and spectroscopic methods. Selected derivatives were evaluated in vitro against several species of aerobic bacteria. Some of them showed activity against S. pyogenes, P. aeruginosa and S. aureus.