1253932-01-2Relevant academic research and scientific papers
Synthesis and biological evaluation of novel coumarin-based inhibitors of Cdc25 phosphatases
Valente, Sergio,Bana, Emilie,Viry, Elodie,Bagrel, Denyse,Kirsch, Gilbert
scheme or table, p. 5827 - 5830 (2010/11/17)
The cell division cycle 25 (Cdc25) family of proteins are dual specificity phosphatases that activate cyclin-dependent kinase (CDK) complexes, which in turn regulate progression through the cell division cycle. Overexpression of Cdc25 proteins has been reported in a wide variety of cancers; their inhibition may thus represent a novel approach for the development of anticancer therapeutics. Herein we report new coumarin-based scaffolds endowed with a selective inhibition against Cdc25A and Cdc25C, being 6a and 6d the most efficient inhibitors and worthy of further investigation as anticancer agents.
