125402-83-7

Upstream product

• 56-41-7 L-alanin 
• 106200-41-3 4-(4-carbomethoxyphenyl)butanal 
• 109-77-3 malononitrile 
• 123910-86-1 4-(4-hydroxybut-1-ynyl)benzoic acid methyl ester 
• 123910-88-3 methyl 4-(4-hydroxybut-1-yl)benzoate 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 124656-56-0 methyl 4-<(4-methylsulfonyloxy)butyl>benzoate 

Downstream Products

• 125402-89-3 diethyl N-<4-<4-(2,4,6-triaminopyrimidin-5-yl)butyl>benzoyl>-L-glutamate 
• 125402-91-7 N-<4-<4-(2,4,6-triaminopyrimidin-5-yl)butyl>benzoyl>-L-glutamic acid 
• 125402-88-2 4-<4-(2,4,6-triaminopyrimidin-5-yl)butyl>benzoic acid 
• 125402-85-9 methyl 4-<4-(2,4,6-triaminopyrimidin-5-yl)butyl>benzoate 

Relevant academic research and scientific papers

Process for the preparation of fused pyridine compounds

Pyrido[2,3-d]pyrimidine compounds are prepared through the reaction of 2,4-diamino-6(1H)-pyrimidone and an activated derivative of a dialdehyde. A typical embodiment utilizes the dinitrile.

A FACILE ROUTE TO "OPEN CHAIN" ANALOGUES OF DDATHF

N-benzoyl>-L-glutamic acid (7-DM-DDATHF, 18) is a representative of a new series of achiral analogues of the potent anticancer agent 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF).Members of this "open chain" pyrimidine series, 18, 19, and 20, were synthesized via guanidine cyclization of 6, 7, and 8 to give the pyrimidines 9, 10, and 11.Ester hydrolysis, glutamate coupling and final saponification yielded the target compounds.