1254055-46-3

Basic information

• Product Name: 3,5-Dichloro-6-ethylpyrazine-2-carbonitrile
• Synonyms: 3,5-Dichloro-6-ethylpyrazine-2-carbonitrile
• CAS NO: 1254055-46-3
• Molecular Formula: C7H5Cl2N3
• Molecular Weight: 202.0407
• Mol File: 1254055-46-3.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3,5-Dichloro-6-ethylpyrazine-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dichloro-6-ethylpyrazine-2-carbonitrile(1254055-46-3)
• EPA Substance Registry System: 3,5-Dichloro-6-ethylpyrazine-2-carbonitrile(1254055-46-3)

Safety Data

• Hazardous Substances Data: 1254055-46-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3,5-Dichloro-6-ethylpyrazine-2-carbonitrile is used as a building block in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 3,5-Dichloro-6-ethylpyrazine-2-carbonitrile serves as a key intermediate in the production of agrochemicals, aiding in the creation of compounds that can protect crops and enhance agricultural yields.
Used in Fragrance Industry:
3,5-Dichloro-6-ethylpyrazine-2-carbonitrile is used as a fragrance ingredient to impart a green, earthy, and musky odor to various products, adding depth and complexity to scents in perfumes, cosmetics, and other fragranced goods.
Used in Fine Chemicals Industry:
3,5-Dichloro-6-ethylpyrazine-2-carbonitrile is also utilized in the synthesis of other fine chemicals, where its unique structure and properties contribute to the creation of specialty chemicals for diverse applications.
Used in Research and Development:
3,5-Dichloro-6-ethylpyrazine-2-carbonitrile is studied for its potential biological activities, including antimicrobial and antifungal properties, indicating its use in research for new treatments and applications in the biomedical field.

Upstream product

• 313340-08-8 3,5-dichloro-6-ethylpyrazine-2-carboxamide 

Downstream Products

• 313340-08-8 3,5-dichloro-6-ethylpyrazine-2-carboxamide 

Relevant articles and documents

Preparation method of Gilteritinib key intermediate

The invention relates to the field of drug synthesis, and particularly discloses a preparation method of a Gilteritinib key intermediate, namely a method for synthesizing a 3,5-dichloro-6-ethylpyrazinecarboxamide intermediate (compound I). The method is novel in route, simple and convenient to operate, high in yield, good in safety and suitable for industrial production, and comprises the following steps: by taking ethyl propionyl acetate as an initial raw material, carrying out hydrolytic acylation to obtain a compound III; carrying out ring closing on the compound III and aminomalononitrilep-toluenesulfonate to obtain a compound V; then carrying out amino diazotization chlorination to obtain a compound VI; carrying out phosphorus oxychloride transposition on the compound VI to obtain 3,5-dichloro-6-ethylpyrazine-2-carbonitrile (a compound VII); and hydrolyzing the compound VII to obtain the 3,5-dichloro-6-ethylpyrazinecarboxamide intermediate (compound I).

DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND

Provided is a compound useful as an inhibitor against the kinase activity of EML4-ALK fusion protein. As a result of intensive and extensive studies on compounds having inhibitory activity against the kinase activity of EML4-ALK fusion protein, the present inventors found that the diamino heterocyclic carboxamide compounds of the present invention had inhibitory activity against the kinase activity of EML4-ALK fusion protein. By this finding, the present invention was completed. The compounds of the present invention can be used as a pharmaceutical composition for preventing and/or treating cancer, such as lung cancer, non-small cell lung cancer, and small cell lung cancer.