1254055-46-3 Usage
General Description
3,5-Dichloro-6-ethylpyrazine-2-carbonitrile is a chemical compound with the molecular formula C8H6Cl2N4. It is a pyrazine derivative with two chlorine atoms at positions 3 and 5, an ethyl group at position 6, and a carbonitrile group at position 2. 3,5-Dichloro-6-ethylpyrazine-2-carbonitrile is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is also known for its potent odor and is used in the fragrance industry to impart a green, earthy, and musky odor to various products. Additionally, it has been studied for its potential biological activities, including its antimicrobial and antifungal properties.
Check Digit Verification of cas no
The CAS Registry Mumber 1254055-46-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,4,0,5 and 5 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1254055-46:
(9*1)+(8*2)+(7*5)+(6*4)+(5*0)+(4*5)+(3*5)+(2*4)+(1*6)=133
133 % 10 = 3
So 1254055-46-3 is a valid CAS Registry Number.
1254055-46-3Relevant articles and documents
Preparation method of Gilteritinib key intermediate
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Paragraph 0022; 0028-0029; 0032; 0038-0039, (2020/07/28)
The invention relates to the field of drug synthesis, and particularly discloses a preparation method of a Gilteritinib key intermediate, namely a method for synthesizing a 3,5-dichloro-6-ethylpyrazinecarboxamide intermediate (compound I). The method is novel in route, simple and convenient to operate, high in yield, good in safety and suitable for industrial production, and comprises the following steps: by taking ethyl propionyl acetate as an initial raw material, carrying out hydrolytic acylation to obtain a compound III; carrying out ring closing on the compound III and aminomalononitrilep-toluenesulfonate to obtain a compound V; then carrying out amino diazotization chlorination to obtain a compound VI; carrying out phosphorus oxychloride transposition on the compound VI to obtain 3,5-dichloro-6-ethylpyrazine-2-carbonitrile (a compound VII); and hydrolyzing the compound VII to obtain the 3,5-dichloro-6-ethylpyrazinecarboxamide intermediate (compound I).
