1254058-33-7

Basic information

• Product Name: 1-[1-(2-methoxy-4-nitrophenyl)piperidin-4-yl]-4-methylpiperazine
• CAS NO: 1254058-33-7
• Molecular Weight: 334.418
• Mol File: 1254058-33-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 488.9±45.0 °C(Predicted)
• Density: 1.195±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-[1-(2-methoxy-4-nitrophenyl)piperidin-4-yl]-4-methylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[1-(2-methoxy-4-nitrophenyl)piperidin-4-yl]-4-methylpiperazine(1254058-33-7)
• EPA Substance Registry System: 1-[1-(2-methoxy-4-nitrophenyl)piperidin-4-yl]-4-methylpiperazine(1254058-33-7)

Safety Data

• Hazardous Substances Data: 1254058-33-7(Hazardous Substances Data)

Usage

General Description

1-[1-(2-methoxy-4-nitrophenyl)piperidin-4-yl]-4-methylpiperazine is a chemical compound with a complex molecular structure. It consists of a piperidine ring with a piperazine ring attached, as well as a methoxy group and a nitro group attached to a phenyl ring. The compound also contains a methyl group. This chemical may have potential pharmacological properties, as compounds containing piperidine and piperazine rings are often found in pharmaceuticals, particularly in the development of new drugs for various medical conditions. However, further research and testing would be needed to determine the specific properties and potential uses of this compound.

Upstream product

• 454-16-0 1-fluoro-2-methoxy-4-nitrobenzene 
• 1219979-73-3 1-methyl-4-(piperidin-4-yl)piperazine monohydrochloride 
• 53617-36-0 1-methyl-4-(piperidin-4-yl)piperazine 

Relevant articles and documents

WEE1 inhibitors as well as preparation and application thereof

The invention relates to WEE1 inhibitors as well as preparation and application thereof. The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, solvates, polymorphs or isomers thereof, and their use in the preparation of medicaments for the treatment of diseases associated with WEE1 activity.

Discovery of N-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N′-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine (ASP3026), a potent and selective anaplastic lymphoma kinase (ALK) inhibitor

Anaplastic lymphoma kinase (ALK) is a validated therapeutic target for treating echinoderm microtubule- associated protein-like 4 (EML4)-ALK positive non-small cell lung cancer (NSCLC). We synthesized a series of 1,3,5-triazine derivatives and identified ASP3026 (14a) as a potent and selective ALK inhibitor. In mice xenografted with NCI-H2228 cells expressing EML4-ALK, once-daily oral administration of 14a demonstrated dose-dependent antitumor activity. Here, syntheses and structure-activity relationship (SAR) studies of 1,3,5-triazine derivatives are described.