1254075-80-3Relevant academic research and scientific papers
Organocatalytic asymmetric 1,4-addition of aldehydes to acridiniums catalyzed by a diarylprolinol silyl ether
Liang, Tao,Xiao, Jian,Xiong, Zhiyi,Li, Xingwei
experimental part, p. 3583 - 3588 (2012/05/20)
The organocatalytic enantioselective 1,4-addition of aldehydes to acridiniums catalyzed by diarylprolinol silyl ether was achieved to furnish chiral acridanes in both high yields (82-96%) and excellent enantioselectivities (up to 99% ee), which also provides the highly enantioselective intermolecular α-alkylation of aldehydes with acridiniums salt.
Electro-organocatalysis: Enantioselective α-alkylation of aldehydes
Ho, Xuan-Huong,Mho, Sun-Il,Kang, Hyuk,Jang, Hye-Young
experimental part, p. 4436 - 4441 (2010/10/02)
The asymmetric organocatalyzed a-alkylation of aldehydes via a cationic radical enamine intermediate was performed under environmentally benign electro-oxidation conditions without the use of chemical, oxidants. To promote the desired a-alkylation reaction of aldehydes, various aldehydes with xanthene or cycloheptatriene groups were exposed to elec-tro-organocatalytic conditions to afford optically active αsubstituted aldehydes (α-alkylated aldehydes) in good yield. A reaction mechanism involving the cationic radical enamine was proposed based on the cyclic voltammetry (CV) results, DFT calculations, and control experiments.
