1254075-88-1Relevant academic research and scientific papers
Electro-organocatalysis: Enantioselective α-alkylation of aldehydes
Ho, Xuan-Huong,Mho, Sun-Il,Kang, Hyuk,Jang, Hye-Young
, p. 4436 - 4441 (2010)
The asymmetric organocatalyzed a-alkylation of aldehydes via a cationic radical enamine intermediate was performed under environmentally benign electro-oxidation conditions without the use of chemical, oxidants. To promote the desired a-alkylation reaction of aldehydes, various aldehydes with xanthene or cycloheptatriene groups were exposed to elec-tro-organocatalytic conditions to afford optically active αsubstituted aldehydes (α-alkylated aldehydes) in good yield. A reaction mechanism involving the cationic radical enamine was proposed based on the cyclic voltammetry (CV) results, DFT calculations, and control experiments.
