1254076-18-0Relevant articles and documents
Scaled-up transition-metal-catalyzed cross-coupling reactions of thioether-substituted N-heterocycles with organozinc reagents
Metzger, Albrecht,Melzig, Laurin,Knochel, Paul
experimental part, p. 2853 - 2858 (2010/10/03)
A variety of functionalized methylthio-substituted N-heterocycles (pyridines, pyrimidines, pyrazines, pyridazines, triazines, quinazolines, benzothiazoles) undergo smooth palladium- or nickel-catalyzed cross-couplings with highly functionalized organozinc reagents at ambient temperature. No expensive copper(I) salts are required and the coupling reactions proceed readily in the range of up to 20 mmol scale. Georg Thieme Verlag Stuttgart.
