125410-18-6

Basic information

• Product Name: 2,5-Piperazinedione,3-methyl-6-(2-methylpropyl)-,trans-(9CI)
• Synonyms: 2,5-Piperazinedione,3-methyl-6-(2-methylpropyl)-,trans-(9CI);(3R,6S)-3-METHYL-6-(2-METHYLPROPYL)PIPERAZINE-2,5-DIONE
• CAS NO: 125410-18-6
• Molecular Formula: C₉H₁₆N₂O₂
• Molecular Weight: 0
• Product Categories: PIPERIDINE
• Mol File: 125410-18-6.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,5-Piperazinedione,3-methyl-6-(2-methylpropyl)-,trans-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Piperazinedione,3-methyl-6-(2-methylpropyl)-,trans-(9CI)(125410-18-6)
• EPA Substance Registry System: 2,5-Piperazinedione,3-methyl-6-(2-methylpropyl)-,trans-(9CI)(125410-18-6)

Safety Data

• Hazardous Substances Data: 125410-18-6(Hazardous Substances Data)

Usage

Structure

Cyclic organic compound containing a piperazine ring and a ketone functional group

Usage

Building block for the preparation of various drugs, including antipsychotics and anti-anxiety medications

Potential use

Treatment of neurodegenerative disorders

Medicinal chemistry potential

Selective or partial agonist for certain neurotransmitter receptors in the brain, valuable for the development of new therapeutic agents.

Upstream product

• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 95083-32-2 (S)-methyl 2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)-4-methylpentanoate 
• 59515-79-6 ((S)-2-aminopropanoyl)-L-leucine methyl ester hydrochloride 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 15761-38-3 L-N-Boc-Ala 
• 905984-90-9 C₂F₆NO₄S₂^(1-)*C₃₈H₅₀N₃O₆⁽¹⁺⁾ 
• 1001249-92-8 C₂F₆NO₄S₂^(1-)*C₃₃H₄₈N₃O₅⁽¹⁺⁾ 
• 4864-39-5 N-carbobenzoxy-L-alanyl-L-leucine methyl ester 
• 24959-68-0 N-Cbz-L-Ala-L-Leu 
• 5845-57-8 L-alanyl-L-leucine methyl ester 
• 7298-84-2 Leu-Ala 

Downstream Products

• 17498-50-9 L-valine hydrochloride 
• 6003-05-0 L-alanine hydrochloride 

Relevant articles and documents

Anti-biofilm and anti-adherence properties of novel cyclic dipeptides against oral pathogens

Microorganisms embedded in a biofilm are significantly more resistant to antimicrobial agents and the defences of the human immune system, than their planktonic counterpart. Consequently, compounds that can inhibit biofilm formation are of great interest for novel therapeutics. In this study, a screening approach was used to identify novel cyclic dipeptides that have anti-biofilm activity against oral pathogens. Five new active compounds were identified that prevent biofilm formation by the cariogenic bacterium Streptococcus mutans and the pathogenic fungus Candida albicans. These compounds also inhibit the adherence of microorganisms to a hydroxylapatite surface. Further investigations were conducted on these compounds to establish the structure–activity relationship, and it was deduced that the common cleft pattern is required for these molecules to act effectively against biofilms.

Cyclic dipeptides exhibit potency for scavenging radicals

Twenty kinds of cyclic dipeptides containing l-leucine were synthesized, and their antioxidant activity against .OH and O2·- was investigated. Compounds possessing polar amino acid residues, such as Asp, Cys, Glu, Lys, Pro, Ser, and Trp, exhibited higher antioxidant activity against .OH than vitamin E. However, only cyclo(l-Cys-l-Leu) scavenged O2·-.

Structures, sensory activity, and dose/response functions of 2,5-diketopiperazines in roasted cocoa nibs (Theobroma cacao)

The taste compounds inducing the blood-like, metallic bitter taste sensation reported recently for a dichloromethane extract prepared from roasted cocoa nibs were identified as a series of 25 diketopiperazines by means of HPLC degustation, LC-MS/MS, and i