1254106-80-3

Basic information

• Product Name: C₁₉H₂₁N₃O₅S
• Synonyms: C₁₉H₂₁N₃O₅S
• CAS NO: 1254106-80-3
• Molecular Weight: 403.459
• Mol File: 1254106-80-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₂₁N₃O₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₂₁N₃O₅S(1254106-80-3)
• EPA Substance Registry System: C₁₉H₂₁N₃O₅S(1254106-80-3)

Safety Data

• Hazardous Substances Data: 1254106-80-3(Hazardous Substances Data)

Upstream product

• 65938-77-4 5-methyl-2-pyridinesulfonamide 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 

Relevant articles and documents

Highly stereoselective and scalable anti-aldol reactions using N-(p-dodecylphenylsulfonyl)-2-pyrrolidinecarboxamide: Scope and origins of stereoselectivities

A highly enantio- and diastereoselective anti-aldol process (up to >99% ee, >99:1 dr) catalyzed by a proline mimetic-N-(p-dodecylphenylsulfonyl)-2- pyrrolidinecarboxamide-has been developed. Catalyst loading as low as 2 mol % can be employed. Use of industry-friendly solvents for this transformation as well as neat reaction conditions have been demonstrated. The scope of this transformation on a range of aldehydes and ketones is explored. Density functional theory computations reveal that the origins of enhanced diastereoselectivity are due to the presence of nonclassical hydrogen bonds between the sulfonamide, the electrophile, and the catalyst enamine that favor the major anti-Re aldol TS in the Houk-List model.