1254121-62-4

Basic information

• Product Name: C₁₇H₂₇N₃
• CAS NO: 1254121-62-4
• Molecular Weight: 273.421
• Mol File: 1254121-62-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₂₇N₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₂₇N₃(1254121-62-4)
• EPA Substance Registry System: C₁₇H₂₇N₃(1254121-62-4)

Safety Data

• Hazardous Substances Data: 1254121-62-4(Hazardous Substances Data)

Upstream product

• 872-53-7 cyclopentanealdehyde 
• 148546-99-0 3-(4-methylpiperazin-1-yl)aniline 

Downstream Products

• 1240529-83-2 naphthalene-2-sulfonic acid cyclopentylmethyl[3-(4-methylpiperazin-1-yl)phenyl]amide 

Relevant articles and documents

Synthesis and SAR of (piperazin-1-yl-phenyl)-arylsulfonamides: A novel series of atypical antipsychotic agents

(Piperazin-1-yl-phenyl)-arylsulfonamides were synthesized and identified to show high affinities for both 5-HT2C and 5-HT6 receptors. Among them, naphthalene-2-sulfonic acid isopropyl-[3-(4-methyl-piperazin-1-yl)- phenyl]-amide (6b) exhibits the highest affinity towards both 5-HT2C (IC50 = 4 nM) and 5-HT6 receptors (IC50 = 3 nM) with good selectivity over other serotonin (5-HT1A, 5-HT 2A, and 5-HT7) and dopamine (D2-D4) receptor subtypes. In 5-HT2C and 5-HT6 receptor functional assays, this compound showed considerable antagonistic activity for both receptors.