1254177-56-4Relevant articles and documents
Solvent-free 2-p-nitrophenyl-3-aryl propionitrile and preparation method thereof
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Paragraph 0058-0062, (2018/04/01)
The invention discloses a solvent-free 2-p-nitrophenyl-3-aryl propionitrile and a preparation method thereof. The preparation method comprises the following steps: adding 4-nitrophenylacetonitrile, aromatic aldehyde, alkali and dihydropyridine ester into a reaction test tube and performing stirring reaction; performing column chromatography to obtain the product 2-p-nitrophenyl-3-aryl propionitrile, wherein the stationary phase used according to the column chromatography is a silica gel column. The problems that the solvent in the prior art is not economic and is not environmentally friendly and the reaction time is long are solved, and the technical gap that the 2-p-nitrophenyl-3-aryl propionitrile is prepared by taking the dihydropyridine ester as a hydrogen source under the solvent-free condition is remedied; by a one-pot method, Knoevenagel and reduction two-step reaction are connected in series, the reaction steps are simplified, and a target product can be obtained efficiently. The dihydropyridine ester serves as the hydrogen source, so compared with the traditional hydrogen source, the hydrogen source has the advantages of no toxicity, mild reaction condition and high chemical selectivity.
Catalyst-free chemoselective reduction of the carbon-carbon double bond in conjugated alkenes with Hantzsch esters in water
He, Qi,Xu, Zhihong,Jiang, Dehong,Ai, Wensi,Shi, Ronghua,Qian, Shan,Wang, Zhouyu
, p. 8671 - 8674 (2014/03/21)
A simple, efficient and green protocol for chemoselective reduction of carbon-carbon double bond in conjugated alkenes with Hantzsch esters is described. Without any additional catalysts, a series of conjugated alkenes with strong electron-withdrawing groups were reduced in water with excellent yield. Functional groups such as nitrile, ester, nitro, fluoro, chloro, bromo, furanyl and benzyl are all tolerated by the reaction conditions employed. The Royal Society of Chemistry.