1254318-98-3Relevant articles and documents
Cathepsin C inhibitors: Property optimization and identification of a clinical candidate
Furber, Mark,Tiden, Anna-Karin,Gardiner, Philip,Mete, Antonio,Ford, Rhonan,Millichip, Ian,Stein, Linda,Mather, Andrew,Kinchin, Elizabeth,Luckhurst, Christopher,Barber, Simon,Cage, Peter,Sanganee, Hitesh,Austin, Rupert,Chohan, Kamaldeep,Beri, Raj,Thong, Bob,Wallace, Alan,Oreffo, Victor,Hutchinson, Ray,Harper, Steve,Debreczeni, Judit,Breed, Jason,Wissler, Lisa,Edman, Karl
, p. 2357 - 2367 (2014/04/17)
A lead generation and optimization program delivered the highly selective and potent CatC inhibitor 10 as an in vivo tool compound and potential development candidate. Structural studies were undertaken to generate SAR understanding.