1254343-08-2Relevant academic research and scientific papers
Bronsted acid-catalyzed enantioselective Friedlaender condensations: Achiral amine promoter plays crucial role in the stereocontrol
Ren, Lei,Lei, Tao,Gong, Liu-Zhu
supporting information; experimental part, p. 11683 - 11685 (2011/12/02)
A highly enantioselective Friedlaender condensation has been established by using chiral Bronsted acids in combination with achiral amines to give quinolines in high yields (up to 99%) and with excellent enantioselectivities (up to 95%).
Catalytic enantioselective Friedlaender condensations: Facile access to quinolines with remote stereogenic centers
Li, Le,Seidel, Daniel
supporting information; experimental part, p. 5064 - 5067 (2010/12/25)
Enamine catalysis enables the first catalytic enantioselective Friedlaender reaction. The desymmetrization of 4-substituted cyclohexanones upon reaction with o-aminobenzaldehydes allows for the synthesis of quinolines with remote stereogenic centers. Thes
