1254353-06-4Relevant articles and documents
Utilization of a nitrogen-sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors
Lin, Shuqun,Wrobleski, Stephen T.,Hynes Jr., John,Pitt, Sidney,Zhang, Rosemary,Fan, Yi,Doweyko, Arthur M.,Kish, Kevin F.,Sack, John S.,Malley, Mary F.,Kiefer, Susan E.,Newitt, John A.,McKinnon, Murray,Trzaskos, James,Barrish, Joel C.,Dodd, John H.,Schieven, Gary L.,Leftheris, Katerina
scheme or table, p. 5864 - 5868 (2010/11/18)
The design, synthesis, and structure-activity relationships (SAR) of a series of 2-aminothiazol-5-yl-pyrimidines as novel p38α MAP kinase inhibitors are described. These efforts led to the identification of 41 as a potent p38α inhibitor that utilizes a un
