1254361-97-1

Basic information

• Product Name: (3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoic acid isopropyl ester
• Synonyms: (3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoic acid isopropyl ester
• CAS NO: 1254361-97-1
• Molecular Weight: 453.554
• Mol File: 1254361-97-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoic acid isopropyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoic acid isopropyl ester(1254361-97-1)
• EPA Substance Registry System: (3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoic acid isopropyl ester(1254361-97-1)

Safety Data

• Hazardous Substances Data: 1254361-97-1(Hazardous Substances Data)

Upstream product

• 1254361-93-7 (S,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-5-hydroxy-3-oxohept-6-enoic acid isopropyl ester 

Downstream Products

• 94061-80-0 fluvastatin sodium 

Relevant articles and documents

Facile and highly enantioselective synthesis of (+)- and (-)-fluvastatin and their analogues

A highly enantioselective synthesis of (+)- and (-)-fluvastatin and their analogues has been facilitated by the reaction of an aldehyde with diketene in the presence of Ti(O-i-Pr)4 and a chiral Schiff base ligand. Either enantiomer of the Schiff base could be employed to obtain (+)- or (-)-fluvastatin. Diastereoselective reductions of the resultant keto moiety of β-hydroxy ketoesters provided the syn-1,3-diol esters (91% ee), which were subsequently recrystallized and saponified to afford (+)- and (-)-fluvastatin in >99.9% ee.