1254364-26-5

Basic information

• Product Name: C₃₄H₃₉BN₄O₇
• CAS NO: 1254364-26-5
• Molecular Weight: 626.517
• Mol File: 1254364-26-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₄H₃₉BN₄O₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₄H₃₉BN₄O₇(1254364-26-5)
• EPA Substance Registry System: C₃₄H₃₉BN₄O₇(1254364-26-5)

Safety Data

• Hazardous Substances Data: 1254364-26-5(Hazardous Substances Data)

Upstream product

• 106778-43-2 isoquinoline-6-carboxylic acid 
• 1158975-01-9 (1R)-1-(L-O-methyltyrosyl-L-valyl)amino-2-(4-methylphenyl)-ethylboronic acid hydrochloride 

Relevant articles and documents

Structure-activity relationship of boronic acid derivatives of tyropeptin: Proteasome inhibitors

The structure-activity relationship of the boronic acid derivatives of tyropeptin, a proteasome inhibitor, was studied. Based on the structure of a previously reported boronate analog of tyropeptin (2), 41 derivatives, which have varying substructure at the N-terminal acyl moiety and P2 position, were synthesized. Among them, 3-phenoxyphenylacetamide 6 and 3-fluoro picolinamide 22 displayed the most potent inhibitory activity toward chymotryptic activity of proteasome and cytotoxicity, respectively. The replacement of the isopropyl group in the P2 side chain to H or Me had negligible effects on the biological activities examined in this study.