1254364-73-2Relevant academic research and scientific papers
The synthesis of paleic acid, an antimicrobial agent effective against Mannheimia and Pasteurella, and its structurally related derivatives
Watanabe, Takumi,Kurata, Ikuko,Hayashi, Chigusa,Igarashi, Masayuki,Sawa, Ryuichi,Takahashi, Yoshikazu,Akamatsu, Yuzuru
supporting information; experimental part, p. 5843 - 5846 (2010/11/19)
A synthetic route to paleic acid 1, antimicrobial agent effective against Mannheimia haemolytica and Pasteurella multocida, has been established. The absolute configuration of the secondary hydroxyl group was controlled by a catalytic asymmetric alkylation of an aldehyde using a chiral titanium sulfonamide complex and the cis double bond was installed using a Wittig reaction. This synthetic route was also applied to the preparation of structurally related analogs, which were used in structure-activity relationship studies for antibacterial activity.
