1254367-40-2

Upstream product

• 100-51-6 benzyl alcohol 
• 13958-93-5 3,5-dichloropyridine-4-carboxylic acid 
• 1254367-43-5 C₂₀H₁₇NO₄ 
• 1254367-38-8 phenyl 5-(benzyloxy)-2-bromo-3-methylisonicotinate 
• 1253799-65-3 phenyl 3-(benzyloxy)-5-methylisonicotinate 
• 1253799-63-1 phenyl 3-(benzyloxy)-5-chloroisonicotinate 
• 1253799-61-9 3-(benzyloxy)-5-chloroisonicotinic acid 
• 1254367-44-6 C₂₀H₁₆BrNO₄ 

Downstream Products

• 1254367-61-7 phenyl 3-(benzyloxy)-6-bromo-2-(dimethylamino)-5-methylisonicotinate 
• 1254367-60-6 phenyl 3-(benzyloxy)-2-bromo-6-(dimethylamino)-5-methylisonicotinate 
• 1254367-67-3 C₂₅H₂₅BrN₂O₅ 
• 1254367-66-2 phenyl 3-(benzyloxy)-2-bromo-6-[(t-butoxycarbonyl)-amino]-5-methylisonicotinate 
• 1254367-68-4 phenyl 2-amino-5-(benzyloxy)-6-bromo-3-methylisonicotinate 
• 1254367-69-5 C₂₀H₁₇BrN₂O₃ 
• 1254367-70-8 phenyl 3-(benzyloxy)-2-bromo-6-fluoro-5-methylisonicotinate 
• 1254367-89-9 C₄₀H₄₅FN₄O₇Si 
• 1254367-90-2 C₄₆H₅₆FN₅O₈Si 
• 1254367-80-0 C₄₂H₅₁N₅O₇Si 
• 1254367-85-5 C₄₈H₆₂N₆O₈Si 
• 1254367-86-6 phenyl 5-benzyloxy-6-[(t-butoxycarbonyl)amino]-2-fluoro-3-methylisonicotinate 
• 1254367-77-5 phenyl 5-benzyloxy-6-[(t-butoxycarbonyl)amino]-2-(dimethylamino)-3-methylisonicotinate 
• 1254367-72-0 C₂₇H₃₂FN₃O₃ 

Relevant academic research and scientific papers

8-azatetracyclines: Synthesis and evaluation of a novel class of tetracycline antibacterial agents

A novel series of fully synthetic 8-azatetracyclines was prepared and evaluated for antibacterial activity. Compounds were identified that overcome both efflux (tet(K)) and ribosomal protection (tet(M)) tetracycline resistance mechanisms and are active against Gram-positive and Gram-negative organisms. Two compounds were identified that exhibit comparable efficacy to marketed tetracyclines in in vivo models of bacterial infection.

8-AZA TETRACYCLINE COMPOUNDS

The present invention is directed to a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use.