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1254473-66-9

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1254473-66-9 Usage

General Description

4-PyridineMethanol, 3,5-dichloro-α-Methyl- is a chemical compound with the molecular formula C8H8Cl2NO, and it is often used in the synthesis of various pharmaceuticals and agrochemicals. It is a white crystalline solid and has a molecular weight of 192.06 g/mol. 4-PyridineMethanol, 3,5-dichloro-α-Methyl- is an important building block in the production of various drugs, including antihypertensive and antimalarial agents. It is also used as an intermediate in the synthesis of other chemical compounds, and its properties make it valuable in the field of organic chemistry for the creation of new and useful molecules. Additionally, it may have potential applications in the field of medicinal chemistry due to its biological activity and potential pharmacological effects.

Check Digit Verification of cas no

The CAS Registry Mumber 1254473-66-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,4,4,7 and 3 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1254473-66:
(9*1)+(8*2)+(7*5)+(6*4)+(5*4)+(4*7)+(3*3)+(2*6)+(1*6)=159
159 % 10 = 9
So 1254473-66-9 is a valid CAS Registry Number.

1254473-66-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(3,5-dichloropyridin-4-yl)ethan-1-ol

1.2 Other means of identification

Product number -
Other names 1-(3,5-dichloropyridin-4-yl)ethan-1-ol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1254473-66-9 SDS

1254473-66-9Relevant articles and documents

VINYL COMPOUNDS AS FGFR AND VEGFR INHIBITORS

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Paragraph 0066; 0076; 0077, (2018/06/23)

FGFR and VEGFR inhibitors are provided, and compounds represented by formula (1) or formula (II) as FGFR and VEGFR inhibitors, pharmaceutically acceptable salts or tautomers thereof are specifically disclosed.

A chiral 1 - (3,5- two chloropyridine -4-yl)-ethanol synthesis method

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Paragraph 0020-0022, (2017/03/28)

The invention discloses an asymmetric synthesis method of 1-(3,5-dichloropyridine-4-yl)-ethanol. The asymmetric synthesis method comprises the following steps: (A) under an action of lithium amide, carrying out a reaction of 3,5-dichloropyridine (I) with acetaldehyde to generate (+/-)-1-(3,5-dichloropyridine-4-yl)-ethanol (II); (B) under an action of an oxidant, allowing (+/-)-1-(3,5-dichloropyridine-4-yl)-ethanol (II) to generate 1-(3,5-dichloropyridine-4-yl)-ethyl ketone (III); and (C) in the presence of a chiral ligand, carrying out a reaction of 1-(3,5-dichloropyridine-4-yl)-ethyl ketone with a borane reagent, and thus obtaining the 1-(3,5-dichloropyridine-4-yl)-ethanol (IV) having a single optical isomer. Compared with traditional chiral column separation of (+/-)-1-(3,5-dichloropyridine-4-yl)-ethanol, the method has the prominent advantages that: (1) the reactions are simple, the operation is easy, the total yield is high, and the optical purity is more than 98%; (2) the industrial preparation period is shortened obviously, and equipment requirements are low; and (3) the preparation cost is low, and the method is suitable for industrial production.

PYRAZOLOPYRIDINES AS INHIBITORS OF THE KINASE LRRK2

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Page/Page column 53, (2011/12/02)

A compound of formula la or formula lb, or a pharmaceutically acceptable salt or ester thereof, wherein R1 is selected from: aryl; heteroaryl; -NHR3; fused aryl-C4-7-heterocycloalkyl; - CONR4R5; -NHCO

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