1254567-68-4Relevant academic research and scientific papers
Pyrazolopyridine inhibitors of B-RafV600E. Part 3: An increase in aqueous solubility via the disruption of crystal packing
Wenglowsky, Steve,Moreno, David,Rudolph, Joachim,Ran, Yingqing,Ahrendt, Kateri A.,Arrigo, Alisha,Colson, Ben,Gloor, Susan L.,Hastings, Gregg
, p. 912 - 915 (2012)
A single crystal was obtained of a lead B-RafV600E inhibitor with low aqueous solubility. The X-ray crystal structure revealed hydrogen-bonded head-to-tail dimers formed by the pyrazolopyridine and sulfonamide groups of a pair of molecules. Thi
