1254578-81-8Relevant articles and documents
Design of a series of bicyclic HIV-1 integrase inhibitors. Part 2: Azoles: Effective metal chelators
Le, Giang,Vandegraaff, Nick,Rhodes, David I.,Jones, Eric D.,Coates, Jonathan A.V.,Thienthong, Neeranat,Winfield, Lisa J.,Lu, Long,Li, Xinming,Yu, Changjiang,Feng, Xiao,Deadman, John J.
scheme or table, p. 5909 - 5912 (2010/11/18)
Synthesis of a diverse set of azoles and their utilizations as an amide isostere in the design of HIV integrase inhibitors is described. The Letter identified thiazole, oxazole, and imidazole as the most promising heterocycles. Initial SAR studies indicat