1254705-46-8Relevant academic research and scientific papers
Acid fluorides as acyl electrophiles in suzuki–miyaura coupling
Ogiwara, Yohei,Sakino, Daisuke,Sakurai, Yuka,Sakai, Norio
supporting information, p. 4324 - 4327 (2018/08/28)
The first palladium-catalyzed construction of ketones through Suzuki–Miyaura reaction by using acid fluorides is described. In contrast to typical acyl electrophiles such as acid chlorides, acid fluorides are uncommon acyl electrophiles to use in boron-based coupling reactions, probably due to a high level of stability toward nucleophiles. This first attempt to use acid fluorides as a coupling partner with boronic acids allowed highly functional group tolerance and a wide substrate scope while affording various ketones in effective yields.
Stereoselective synthesis of cyclohexanones via phase transfer catalyzed double addition of nucleophiles to divinyl ketones
Silvanus, Andrew C.,Groombridge, Benjamin J.,Andrews, Benjamin I.,Kociok-Koehn, Gabriele,Carbery, David R.
supporting information; experimental part, p. 7491 - 7493 (2010/12/30)
Functionalized cyclohexanones are formed in excellent yield and diastereoselectivity from a phase transfer catalyzed double addition of active methylene pronucleophiles to nonsymmetrical divinyl ketones.
