1254730-40-9

Basic information

• Product Name: 2-Fluoro-3-methylsulfonylpyridine
• Synonyms: 2-Fluoro-3-methylsulfonylpyridine;2-Fluoro-3-methanesulfonyl-pyridine
• CAS NO: 1254730-40-9
• Molecular Formula: C6H6FNO2S
• Molecular Weight: 175.1807432
• Mol File: 1254730-40-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 353.5±42.0 °C(Predicted)
• Appearance: /
• Density: 1.361±0.06 g/cm3(Predicted)
• PKA: -3.98±0.10(Predicted)
• CAS DataBase Reference: 2-Fluoro-3-methylsulfonylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-3-methylsulfonylpyridine(1254730-40-9)
• EPA Substance Registry System: 2-Fluoro-3-methylsulfonylpyridine(1254730-40-9)

Safety Data

• Hazardous Substances Data: 1254730-40-9(Hazardous Substances Data)

Upstream product

• 210992-56-6 2-fluoro-3-methylthiopyridine 

Relevant articles and documents

Intrinsic electrophilicity of the 4-methylsulfonyl-2-pyridone scaffold in glucokinase activators: Role of glutathione-S-transferases and in vivo quantitation of a glutathione conjugate in rats

Previous studies on the in vitro metabolism of 4-alkylsulfonyl-2-pyridone- based glucokinase activators revealed a facile, non-enzymatic displacement of the 4-alkylsulfonyl group by glutathione. In the present studies, a role for glutathione-S-transferases (GST) as catalysts in the desulfonylation reaction was demonstrated using a combination of human liver microsomes, human liver cytosol and human GSTs. The identification of a glutathione conjugate in circulation following intravenous administration of a candidate 4-methylsulfonyl-2-pyridone to rats confirmed the relevance of the in vitro findings.