1254841-02-5Relevant academic research and scientific papers
Asymmetric synthesis of telcagepant, a CGRP receptor antagonist for the treatment of migraine
Xu, Feng,Zacuto, Michael,Yoshikawa, Naoki,Desmond, Richard,Hoerrner, Scott,Itoh, Tetsuji,Journet, Michel,Humphrey, Guy R.,Cowden, Cameron,Strotman, Neil,Devine, Paul
supporting information; scheme or table, p. 7829 - 7841 (2011/02/22)
A highly efficient, asymmetric synthesis of telcagepant (1), a CGRP receptor antagonist for the treatment of migraine, is described. This synthesis features the first application of iminium organocatalysis on an industrial scale. The key to the success of
