125486-36-4Relevant academic research and scientific papers
INHIBITORS OF LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LMPTP) AND USES THEREOF
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Paragraph 00211; 00212; 00213, (2019/07/20)
Protein tyrosine phosphatases (PTPs) are key regulators of metabolism and insulin signaling. As a negative regulator of insulin signaling, the low molecular weight protein tyrosine phosphatase (LMPTP) is a target for insulin resistance and related conditions. Described herein are compounds capable of modulating the level of activity of LMPTP, compositions, and methods of using these compounds and compositions.
Adenine and uracil derivatives with antitubercular activity
Alksnis,Korneeva,Lukevics
, p. 743 - 746 (2007/10/03)
We have carried out the synthesis and investigated the antitubercular activity of adenine and 5-fluorouracil derivatives. It was found that a comparatively large, lipophilic fragment is needed in the active molecule to inhibit the tuberculosis pathogen.
SYNTHESIS OF N,N,9-TRISUBSTITUTED ADENINES UNDER CONDITIONS OF PHASE-TRANSFER CATALYSIS
Ramzaeva, N. P.,Gol'dberg, Yu. Sh.,Alksnis, E. R.,Lidak, M. Yu.,Shimanskaya, M. V.
, p. 1611 - 1615 (2007/10/02)
Alkylation of N-mono- and N,N-disubstituted adenines by 2,6-dichlorobenzyl chlorides under the conditions of phase-transfer catalysis in the benzene-50percent aqueous sodium hydroxide system takes place regioselectively with the formation of the corresponding N,N,9-trisubstituted adenines (60-80percent).The isomeric N,N,3-trisubstituted adenines are also formed.The N,9-disubstituted adenines are alkylated regiospecifically under analogous conditions and give N,N,9-trisubstituted adenines with quantitative yields.
