1254926-30-1

Basic information

• Product Name: 3-(1-(4-chlorobenzyl)-1H-1,2,3-triazol-4-yl)-1H-pyrrolo[2,3-b]pyridine
• CAS NO: 1254926-30-1
• Molecular Weight: 309.758
• Mol File: 1254926-30-1.mol

Chemical Properties

• CAS DataBase Reference: 3-(1-(4-chlorobenzyl)-1H-1,2,3-triazol-4-yl)-1H-pyrrolo[2,3-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1-(4-chlorobenzyl)-1H-1,2,3-triazol-4-yl)-1H-pyrrolo[2,3-b]pyridine(1254926-30-1)
• EPA Substance Registry System: 3-(1-(4-chlorobenzyl)-1H-1,2,3-triazol-4-yl)-1H-pyrrolo[2,3-b]pyridine(1254926-30-1)

Safety Data

• Hazardous Substances Data: 1254926-30-1(Hazardous Substances Data)

Upstream product

• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 192189-18-7 tert-butyl 3-iodo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate 
• 23616-57-1 3-iodo-1H-pyrrolo[2,3-b]pyridine 
• 1352786-69-6 tert-butyl 3-ethynylpyrrolo[2,3-b]pyridine-1-carboxylate 
• 271-63-6 7-Azaindole 

Relevant articles and documents

3-(1,2,3-Triazol-4-yl) pyrrolo [2,3-b] pyridine derivatives

Compounds of the formula (I), in which R1, R2 and R3 have the meanings indicated in claim (1), are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed for the treatment of tumours.

Rapid preparation of triazolyl substituted NH-heterocyclic kinase inhibitors via one-pot Sonogashira coupling-TMS-deprotection-CuAAC sequence

The one-pot, three-component Sonogashira coupling-TMS-deprotection-CuAAC ("click") sequence is the key reaction for the rapid synthesis of triazolyl substituted N-Boc protected NH-heterocycles, such as indole, indazole, 4-, 5-, 6-, and 7-azaindoles, 4,7-diazaindole, 7-deazapurines, pyrrole, pyrazole, and imidazole. Subsequently, the protective group was readily removed to give the corresponding triazolyl derivatives of these tremendously important NH-heterocycles. All compounds have been tested in a broad panel of kinase assays. Several compounds, 8f, 8h, 8k, and 8l, have been shown to inhibit the kinase PDK1, a target with high oncology relevance, and thus they are promising lead structures for the development of more active derivatives. The X-ray structure analysis of compound 8f in complex with PDK1 has revealed the detailed binding mode of the molecule in the kinase. The Royal Society of Chemistry 2011.