125494-93-1

Basic information

• Product Name: Silane, (1,1-dimethylethyl)dimethyl[(1-methyl-2-propynyl)oxy]-
• Synonyms: 2-TERT-BUTYLDIMETHYLSILOXYBUT-3-YNE;2-tert-Butyldimethylsiloxybut-3-yne 97%;TERT-BUTYL-DIMETHYL-(METHYL-PROP-2-YNLOXY)SILANE;Silane, (1,1-dimethylethyl)dimethyl[(1-methyl-2-propyn-1-yl)oxy]-
• CAS NO: 125494-93-1
• Molecular Formula: C₁₀H₂₀OSi
• Molecular Weight: 184.35
• Mol File: 125494-93-1.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 40-42 °C/9 mbar
• Flash Point: 39 °C
• Appearance: /
• Density: 0.812 g/mL at 25 °C
• Refractive Index: n 20/D 1.423
• CAS DataBase Reference: Silane, (1,1-dimethylethyl)dimethyl[(1-methyl-2-propynyl)oxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, (1,1-dimethylethyl)dimethyl[(1-methyl-2-propynyl)oxy]-(125494-93-1)
• EPA Substance Registry System: Silane, (1,1-dimethylethyl)dimethyl[(1-methyl-2-propynyl)oxy]-(125494-93-1)

Safety Data

• Statements: 10
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 125494-93-1(Hazardous Substances Data)

Upstream product

• 26826-40-4 tert-butyl 1-methyl-2-propynyl ether 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 2028-63-9 but-3-yn-2-ol 

Downstream Products

• 127914-88-9 4-((tert-Butyldimethylsilyl)oxy)-1-(2',6',6'-trimethylcyclohexen-1'-yl)pent-2-yn-1-ol 
• 161945-38-6 2-(tert-Butyl-dimethyl-silanyloxy)-15-(4-methoxy-benzyloxy)-pentadec-3-yn-6-ol 
• 195534-85-1 tert-Butyl-dimethyl-(1-methyl-6-trityloxy-oct-7-en-2-ynyloxy)-silane 
• 904962-37-4 5-[3-(tert-butyl-dimethyl-silanyloxy)-but-1-ynyl]-2-(4-phenoxy-phenoxy)-thiazole 
• 543725-08-2 acetic acid 4-(tert-butyl-dimethyl-silanyloxy)-1-propenyl-1-trityloxymethyl-pent-2-ynyl ester 
• 1265903-83-0 4-(tert-butyldimethylsilyloxy)-1-cyclohexylpent-2-yn-1-ol 
• 99206-61-8 (+/-)-hex-4-yn-2-ol 
• 1584224-52-1 C₂₀H₃₁NO₃SSi 

Relevant articles and documents

Rhodium- or iridium-catalyzed trans-hydroboration of terminal alkynes, giving (Z)-1-alkenylboron compounds [6]

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Rhodium-catalyzed hydroformylation of 1,1-disubstituted allenes employing the self-assembling 6-DPPon system

Abstract A rhodium-catalyzed hydroformylation of 1,1-disubstituted allenes is reported. Using a RhI/6-DPPon catalyst system, one can obtain β,γ-unsaturated aldehydes in high regio- and chemoselectivity. The Z-configured product is formed with up to >95% selectivity when unsymmetrically 1,1-disubstituted allenes are submitted to the reaction conditions. This is the first time that these interesting building blocks are accessible by hydroformylation of allenes. The utility of this methodology is demonstrated by further transformations of one of the obtained products. β,γ-Unsaturated aldehydes are obtained by a rhodium-catalyzed hydroformylation of 1,1-disubstituted allenes. For unsymmetrically 1,1-disubstituted allenes the Z-configured product is formed in up to about 95% selectivity. This is the first time that these building blocks are accessible by hydroformylation of allenes. The utility of this methodology is demonstrated by further transformations of one of the obtained products.

Lipase-catalyzed highly enantioselective kinetic resolution of boron-containing chiral alcohols

The first application of enzymes as catalysts to obtain optically pure boron compounds is described. The kinetic resolution of boron-containing chiral alcohols via enantioselective transesterification catalyzed by lipases was studied. Aromatic, allylic, and aliphatic secondary alcohols containing a boronate ester or boronic acid group were resolved by lipase from Candida antartica (CALB), and excellent E values (E > 200) and high enantiomeric excesses (up to >99%) of both remaining substrates and acetylated product were obtained.