1254940-21-0

Basic information

• Product Name: C₂₇H₃₀N₄O₃S
• CAS NO: 1254940-21-0
• Molecular Weight: 490.626
• Mol File: 1254940-21-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₇H₃₀N₄O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₃₀N₄O₃S(1254940-21-0)
• EPA Substance Registry System: C₂₇H₃₀N₄O₃S(1254940-21-0)

Safety Data

• Hazardous Substances Data: 1254940-21-0(Hazardous Substances Data)

Upstream product

• 660836-08-8 1-(5-phenyl-thieno[2,3-d]pyrimidine-4-yl)-piperidin-4-ylamine 
• 2210-74-4 2-(2-methoxy-phenoxymethyl)-oxirane 

Relevant articles and documents

Thienopyrimidines as β3-adrenoceptor agonists: Hit-to-lead optimization

Resulting from a vHTS based on a pharmacophore alignment on known β3-adrenoceptor ligands, an aryloxypropanolamine scaffold comprising a thienopyrimidine moiety was further optimized as a human β3-AR agonist, yielding a lead compound with an excellent cellular activity of EC50 = 20 pM, selectivity over hβ1- and hβ2-adrenoceptors and a promising safety profile.