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1254975-01-3

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1254975-01-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1254975-01-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,4,9,7 and 5 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1254975-01:
(9*1)+(8*2)+(7*5)+(6*4)+(5*9)+(4*7)+(3*5)+(2*0)+(1*1)=173
173 % 10 = 3
So 1254975-01-3 is a valid CAS Registry Number.

1254975-01-3Upstream product

1254975-01-3Downstream Products

1254975-01-3Relevant academic research and scientific papers

Discovery of pyrrolopyridazines as novel DGAT1 inhibitors

Fox, Brian M.,Iio, Kiyosei,Li, Kexue,Choi, Rebeka,Inaba, Takashi,Jackson, Simon,Sagawa, Shoichi,Shan, Bei,Tanaka, Masahiro,Yoshida, Atsuhito,Kayser, Frank

scheme or table, p. 6030 - 6033 (2010/11/05)

A new structural class of DGAT1 inhibitors was discovered and the structure-activity relationship was explored. The pyrrolotriazine core of the original lead molecule was changed to a pyrrolopyridazine core providing an increase in potency. Further exploration resulted in optimization of the propyl group at C7 and the discovery that the ester at C6 could be replaced by five-membered heterocyclic rings. The analogs prepared have DGAT1 IC 50 values ranging from >10 μM to 48 nM.

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