125498-92-2Relevant academic research and scientific papers
Versatile supramolecular pH-tolerant hydrogels which demonstrate pH-dependent selective adsorption of dyes from aqueous solution
Okesola, Babatunde O.,Smith, David K.
, p. 11164 - 11166 (2013)
We report a novel gelator functionalised with hydrazides (as replacements for carboxylic acids) which, as a result, is able to assemble into hydrogels across a wide pH range-this gelator exhibits pH-switchable dye adsorption-desorption dependent on protonation of the target dyes and their resulting interactions with the self-assembled gel nanofibres.
Two-component supramolecular hydrogel for controlled drug release
Patterson, Anna K.,Smith, David K.
, p. 11046 - 11049 (2020)
A hybrid gel has been developed by combining two supramolecular gelators. Each gelator endows the hybrid gel with its own characteristics. One gelator enables pH-mediated controlled release of the active pharmaceutical ingredient naproxen, while the other new gelator enhances mechanical stability. Self-assembly thus gives multi-functional gels with potential applications.
Multidomain hybrid hydrogels: Spatially resolved photopatterned synthetic nanomaterials combining polymer and low-molecular-weight gelators
Cornwell, Daniel J.,Okesola, Babatunde O.,Smith, David K.
, p. 12461 - 12465 (2014)
A simple approach to a patterned multidomain gel is reported, combining a pH-responsive low-molecular-weight gelator (LMWG) and a photoinducible polymer gelator (PG). Using SEM (scanning electron microscopy), NMR spectroscopy, and CD, we demonstrate that self-assembly of the LMWG network occurs in the presence of the PG network, but that the PG has an influence on LMWG assembly kinetics and morphology. The application of a mask during photoirradiation allows patterning of the PG network; we define the resulting system as a multidomain gel -one domain consists of a LMWG, whereas the patterned region contains both LMWG and PG networks. The different domains have different properties with regard to diffusion of small molecules, and both gelator networks can control diffusion rates to give systems capable of controlled release. Such materials may have future applications in multikinetic control of drug release, or as patterned scaffolds for directed tissue engineering.
Sorbitol diacetal phase selective supramolecular gel factor and preparation method and application thereof
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Paragraph 0023, (2017/01/23)
The invention discloses a sorbitol diacetal phase selective supramolecular gel factor, and a preparation method and application thereof. The gel is shown by a general formula I, wherein R represents (CH2)4CH3 or (CH2)10CH3). The sorbitol diacetal phase se
Hybrid polymer and low molecular weight gels-dynamic two-component soft materials with both responsive and robust nanoscale networks
Cornwell, Daniel J.,Okesola, Babatunde O.,Smith, David K.
, p. 8730 - 8736 (2013/09/12)
Hybrid hydrogels combining both a low molecular weight gelator (LMWG, 1,3:2,4-dibenzylidene-d-sorbitol-p,p′-dicarboxylic acid) and a polymer gelator (PG, agarose) are reported. The dynamic assembly of the LMWG is explored in the absence and presence of the PG using NMR and CD methods. It is shown that the LMWG still assembles into chiral nanofibres in the presence of a nanoscale PG network, although the kinetics of assembly are somewhat modified. As such, these hybrid materials can be considered as self-sorting multi-gelator gels. Importantly, the LMWG retains its pH-responsive character and can be assembled and disassembled within the PG network, which acts to retain the overall integrity of the gel. As such, these materials demonstrate how the responsive nature of an LMWG can be combined with the greater resilience of a PG network to yield novel materials with hybrid performance.
