125511-47-9Relevant academic research and scientific papers
First Total Synthesis of the Marine-Derived Anti-inflammatory Natural Product (-)-Herdmanine D through a Steglich Esterification
Sharma, Pankaj,Sharma, Nutan,Kashyap, Gunjan,Bhagat, Sunita
supporting information, p. 62 - 65 (2021/11/26)
An efficient and regioselective route for the first total synthesis of the antiinflammatory marine natural product ( )-herdmanine D, with an excellent overall yield of 18%, is described. A key feature of the synthetic strategy is a Steglich esterification of regioselectively constructed 6-bromo-5-methoxy-1H-indole-3-carboxylic acid with protected L-tyrosine. The formation of the L-isomer was confirmed through measurement of the optical activity. The current strategy paves the way for the construction of diverse analogues of ( )-herdmanine D for drug development.
Phospholipid gel compositions for delivery of aptamers and methods of treating conditions using same
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Page/Page column 31, (2010/11/27)
The present invention relates to pharmaceutical compositions in the form of a gel for controlled- or sustained-release of an aptamer and to methods for treating or preventing a condition in an animal by administering to an animal in need thereof the pharm
Pharmaceutical compositions for the administration of aptamers
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Page/Page column 27, (2010/11/27)
Pharmaceutical compositions comprising an aptamer and an amino acid ester or amide or an aptamer; a divalent metal cation; and a carboxylic acid, a phospholipid, a phosphatidyl choline, or a sphingomyelin. Methods of treating or preventing a condition in
Compositions for controlled delivery of pharmaceutically active compounds
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Page/Page column 19, (2008/06/13)
The invention relates to pharmaceutical compositions that provide sustained-release of a pharmaceutically active compound and to methods of treating or preventing a condition in an animal by administering the pharmaceutical compositions to the animal by i
