1255150-86-7Relevant academic research and scientific papers
Enantioselective total synthesis of (-)- and (+)-petrosin
Toya, Hiroki,Okano, Kentaro,Takasu, Kiyosei,Ihara, Masataka,Takahashi, Atsushi,Tanaka, Haruo,Tokuyama, Hidetoshi
supporting information; experimental part, p. 5196 - 5199 (2011/02/23)
The enantioselective total synthesis of (-)- and (+)-petrosin is described. The union of two key segments was executed by Suzuki-Miyaura coupling. The quinolizidine rings were stereoselectively constructed via a diastereoselective Mannich reaction and an aza-Michael reaction. The 16-membered ring was constructed by ring-closing metathesis with the second-generation Grubbs catalyst.
