1255154-22-3Relevant academic research and scientific papers
Chiral-Sc catalyzed asymmetric Michael addition/protonation of thiols with enones in water
Kitanosono, Taku,Sakai, Masaru,Ueno, Masaharu,Kobayashi, Shu
experimental part, p. 7134 - 7147 (2012/10/08)
Asymmetric Michael reactions and enantioselective protonations between enones and thiols were catalyzed by a Sc(OTf)3-chiral 2,2′-bipyridine complex in water. The remarkable governing of the enantioselectivity for simple introduction of protons despite their abnormally high mobility in water may provide us with new synthetic opportunities as well as significant chemical advances.
Chiral Sc-catalyzed asymmetric Michael reactions of thiols with enones in water
Ueno, Masaharu,Kitanosono, Taku,Sakai, Masaru,Kobayashi, Sh
supporting information; scheme or table, p. 3619 - 3621 (2011/06/10)
Asymmetric Michael reactions of thiols with enones were catalyzed by a Sc(OTf)3-chiral bipyridine complex at room temperature in water without using any organic solvents, to afford the desired sulfides in high yields with high enantioselectivities.
A bifunctional cinchona alkaloid-squaramide catalyst for the highly enantioselective conjugate addition of thiols to transchalcones
Dai, Le,Wang, Su-Xi,Chen, Fen-Er
supporting information; experimental part, p. 2137 - 2141 (2010/11/05)
A chiral squaramide catalysts-promoted asymmetric sulfa-Michael conjugated addition of thiols to trans-chalcones is presented. Moderate to excellent yields and high enantioselectivities (up to 99% ee) were achieved under mild conditions.
