1255205-77-6

Basic information

• Product Name: 4-(2-{4-[2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazin-1-yl}-1-methylethyl)-2-(methyloxy)benzonitrile
• Synonyms: 4-(2-{4-[2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazin-1-yl}-1-methylethyl)-2-(methyloxy)benzonitrile
• CAS NO: 1255205-77-6
• Molecular Weight: 449.55
• Mol File: 1255205-77-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-{4-[2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazin-1-yl}-1-methylethyl)-2-(methyloxy)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-{4-[2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazin-1-yl}-1-methylethyl)-2-(methyloxy)benzonitrile(1255205-77-6)
• EPA Substance Registry System: 4-(2-{4-[2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazin-1-yl}-1-methylethyl)-2-(methyloxy)benzonitrile(1255205-77-6)

Safety Data

• Hazardous Substances Data: 1255205-77-6(Hazardous Substances Data)

Upstream product

• 1255207-22-7 2-methoxy-4-(1-oxopropan-2-yl)benzonitrile 
• 1255206-81-5 1-[2-hydroxy-2-(4-methyl-1oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazin-1-ium chloride 

Relevant articles and documents

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

This invention relates to compounds having structural Formula I: and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure