1255206-70-2

Basic information

• Synonyms: (R)-4-methyl-5-(oxiran-2-yl)isobenzofuran-1(3H)-one
• CAS NO: 1255206-70-2
• Molecular Formula: C₁₁H₁₀O₃
• Molecular Weight: 190.2
• Mol File: 1255206-70-2.mol
• Article Data: 33

Chemical Properties

• Boiling Point: 432.6±45.0 °C(Predicted)
• Appearance: /
• Density: 1.345±0.06 g/cm3(Predicted)
• CAS DataBase Reference: N/A(CAS DataBase Reference)
• NIST Chemistry Reference: N/A(1255206-70-2)
• EPA Substance Registry System: N/A(1255206-70-2)

Safety Data

• Hazardous Substances Data: 1255206-70-2(Hazardous Substances Data)

Usage

General Description

The chemical (R)-4-methyl-5-(oxiran-2-yl)isobenzofuran-1(3H)-one is a compound with a complex structure that includes a oxiran-2-yl group and a methyl group. It is also known as epoxyketone and isobenzofurandione. This chemical is commonly used in organic synthesis and can be found in various research and industrial applications. It is important to handle this compound with care, as it may pose health risks if not properly managed. Additionally, its unique structure and reactivity make it a valuable tool in the development of new materials and pharmaceuticals.

Upstream product

• 1255206-75-7 1,3-dihydro-1-oxo-4-methyl-5-(2-bromoacetyl)isobenzofuran 
• 67-63-0 isopropyl alcohol 
• 1255206-68-8 4-methyl-5-oxiran-2-yl-2-benzofuran-1(3H)-one 
• 1255206-69-9 5-ethenyl-4-methyl-2-benzofuran-1(3H)-one 
• 1255206-67-7 5-bromo-4-methyl-2-benzofuran-1(3H)-one 
• 83647-43-2 3-bromo-2-methylbenzyl alcohol 
• 76006-33-2 3-bromo-2-methylbenzoic acid 
• 1255206-74-6 5-(1-butoxy-vinyl)-4-methyl-3H-isobenzofuran-1-one 
• 1255206-73-5 trifluoromethanesulfonic acid 4-methyl-1-oxo-1,3-dihydro-isobenzofuran-5-yl ester 
• 1194700-73-6 5-hydroxy-4-methyl-3H-isobenzofuran-1-one 
• 1255206-72-4 6-bromo-3-hydroxy-2-methylbenzenemethanol 
• 54874-26-9 3-hydroxymethyl-2-methylphenol 
• 603-80-5 3-hydroxy 2-methylbenzoic acid 
• 1548296-37-2 4-methyl-5-(trimethylstannyl)isobenzofuran-1(3H)-one 

Downstream Products

• 1431943-79-1 6-fluoro-3-({4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-2-oxopiperazin-1-yl}acetyl)-2-methylbenzonitrile 
• 1431943-78-0 3-({4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-2-oxopiperazin-1-yl}acetyl)-6-methoxy-2-methylbenzonitrile 

Relevant articles and documents

Bio- And Chemocatalysis for the Synthesis of Late Stage SAR-Enabling Intermediates for ROMK Inhibitors and MK-7145 for the Treatment of Hypertension and Heart Failure

A synthetic strategy to provide two late-stage intermediates for the synthesis of diverse analogues of ROMK inhibitors for the treatment of hypertension and heart failure is described. Key transformations include carbonylation of a bromoarene, regioselect

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylax

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula Ia and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.